Research | Highlights

Phenylboronic Acid Functionalized Polycarbonate Hydrogels for Controlled Release of Polymyxin B in Pseudomonas aeruginosa Infected Burn Wounds

While physically crosslinked polycarbonate hydrogels are effective drug delivery platforms, their hydrophobic nature and lack of side chain functionality or affinity ligands for controlled release of hydrophilic drugs underscore the importance of their chemical compositions. Our lab reported an array of anionic hydrogel systems of phenylboronic acid functionalized triblock copolymers with similar core structural features prepared via reversible physical interactions. The optimum gel systems obtained from the meta-substituted copolymers (m-PAP) were stable at physiological pH, non-toxic to mammalian dermal cells, demonstrate controlled in vitro drug release kinetics and in vitro and in vivo antimicrobial activity against P. aeruginosa over 48 h.  The current strategy described in this study demonstrates a straightforward approach in designing physiologically relevant boronic acid hydrogel systems for controlled release of cationic antimicrobials for future clinical applications.